Evaluation of Cerium Oxide Nanoparticles coated with Anti-Interleukin 17 Aptamer in Reducing of Brain Inflammation and Degree of Disease in the Model of Multiple Sclerosis

Document Type : Original Article

Authors

1 Imam Reza Complex, Department of Laboratory Sciences, Faculty of Paramedicine, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 *Assistant Professor, Department of Laboratory Science, Faculty of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background and Aims: Multiple sclerosis (MS) is an inflammatory neurological disorder that causes physical disability in young people, especially in women. The purpose of this study was to evaluate the effect of cerium oxide nanoparticles coated with anti-interleukin-17 aptamer in reducing the inflammation of the brain and the degree of disease in the mice with MS.
Materials and Methods: This study was an experimental study, and the disease model was first developed using extracts including PLP and MBP. Then the cerium oxide nanoparticles coated with Anti-Interleukin 17 aptamer were injected into animal models. After sensory and motor evaluation of the mice, the expression of some inflammatory genes (interleukin 17, interleukin 10, and interleukin 6 and interferon gamma) was evaluated.
Results: This study showed that myelin extract was not able to develop a disease model, but PLP and MBP extracts were able to produce good disease. Cerium oxide nanoparticles coated with anti-interleukin 17 aptamer could not affect on symptom but could decrease some genes such as the interleukin 17 gene and interleukin 6 in the third week and reduce inflammation to some extent.
Conclusion: It can be concluded that Serum oxidized nanoparticles coated with anti-interleukin 17 aptamer can somehow prevent the progression of the disease. However, the pharmacodynamics and pharmacokinetics of this nanodrug should be evaluated in future studies.

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