Survey on Antibiotic Resistance Pattern and Prevalence Determination of Carbapenemase-Producing Acinetobacter in Patient Samples, Using Hodge phenotypic Test

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Background and Aims: Nowadays, Acinetobacter is resistant to a wide range of antibiotics. One reason for resistance to carbapenems, is carbapenemase enzyme production by this bacterium. The research aimed to determine the prevalence rate of carbapenemases in Acinetobacter and antibiotic resistance patterns.
Materials and Methods: In this cross-sectional study, 33 Acinetobacters were collected during a 9 month period, tertiary Hospitals of Sanandaj in 2013. Then, isolated Acinetobacters were proved and identified using biochemical tests, again. The antibiotic susceptibility test was performed by disk diffusion method. Also using Hodge phenotypic test and according to Clinical & Laboratory Standards Institute (CLSI) guidelines, carbapenemase enzyme producer isolates were isolated and identified. T-test and SPSS18 software were used for data analysis (p-value <0.05).
Results: Highest antibiotic resistance were related to ceftriaxone (100%) and cefotaxime (100%) and 26 Acinetobacters isolates were carbapenemase enzyme producer. Based on the statistical results, there was no significant correlation between sex (male and female) and antibiotic resistance (p-value>0.05).
Conclusion: This study revealed that Acinetobacter isolated from patients were antibiotic-resistant and carbapenemase producers. Accordingly, determination of appropriate programs for control and prevention of the Acinetobacter prevalence with antibiotic-resistant is required

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